AskDefine | Define clot

Dictionary Definition

clot n : a lump of material formed from the content of a liquid [syn: coagulum]


1 change from a liquid to a thickened or solid state; "coagulated blood" [syn: coagulate]
2 cause to change from a liquid to a solid or thickened state [syn: coagulate]
3 turn into curds; "curdled milk" [syn: curdle, clabber] [ant: homogenize, homogenize, homogenize]
4 coalesce or unite in a mass; "Blood clots" [syn: clog] [also: clotting, clotted]

User Contributed Dictionary



  • /klɒt/
    Rhymes with: -ɒt


  1. A solidified drop of blood.
  2. A silly person.


blood clot
  • Finnish: hyytynyt veripisara
  • French: caillot
  • German: Blutgerinnsel
  • Hungarian: vérrög
  • Italian: coagulo
  • Spanish: coágulo
a silly person
  • Finnish: typerys
  • German: Trottel


  1. To form into a slimy mass.


to form into a slimy mass
  • German: Klumpen bilden, klumpen



  1. pit

Extensive Definition

A thrombus, or blood clot, is the final product of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system (i.e. clotting factors). A thrombus is physiologic in cases of injury, but pathologic in case of thrombosis.
Specifically, a thrombus is a blood clot in an intact blood vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel. In a small blood vessel, blood flow may be completely cut-off resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is an embolus.
Some of the conditions which elevate risk of blood clots developing include atrial fibrillation (a form of cardiac arrhythmia), heart valve replacement, a recent heart attack, extended periods of inactivity (see deep venous thrombosis), and genetic or disease-related deficiencies in the blood's clotting abilities.
Blood clot prevention reduces the risk of stroke, heart attack and pulmonary embolism. Heparin and warfarin are often used to inhibit the formation and growth of existing blood clots; they are able to decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidated vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII.
Virchow's Triad describes the conditions necessary for thrombus formation:
  1. Changes in vessel wall morphology (e.g. trauma, atheroma)
  2. Changes in blood flow through the vessel (e.g. valvulitis, aneurysm)
  3. Changes in blood composition (e.g. leukaemia, hypercoagulability disorders)
Disseminated intravascular coagulation (DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and fibrinolysis using all of the body's available platelets and clotting factors. The end result is ischaemic necrosis of the affected tissue/organs and spontaneous bleeding due to the lack of clotting factors. Causes are septicaemia, acute leukaemia, shock, snake bites or severe trauma. Treatment involves the use of fresh, frozen plasma to restore the level of clotting factors in the blood.

See also

External links

clot in Arabic: جلطة
clot in German: Thrombus
clot in Spanish: Trombosis
clot in Esperanto: Trombo
clot in French: Thrombus
clot in Italian: Trombo
clot in Lithuanian: Trombas
clot in Hungarian: Thrombus
clot in Japanese: 血栓
clot in Polish: Zakrzep
clot in Portuguese: Trombo
clot in Quechua: Sirk'a unquy
clot in Russian: Тромб
clot in Swedish: Blodpropp
clot in Danish: Blodprop

Synonyms, Antonyms and Related Words

Devonshire cream, adhere, agglomerate, agglomeration, ament, array, assemble, batch, battery, beat up, blockhead, blood clot, blunderer, blunderhead, body, bonnyclabber, boor, born fool, botcher, breccia, bumbler, bunch, bunch up, bundle, bungler, cake, casein, churn, clabber, clasp, cleave, clinch, cling, cling to, clod, clodhopper, clodknocker, clotted cream, clown, clump, cluster, coagulate, coagulum, cohere, collect, colloid, colloidize, come together, concrete, concretion, congeal, congenital idiot, conglomerate, conglomeration, congregate, converge, copulate, couple, crassamentum, cream, cretin, crowd, curd, curdle, date, defective, dolt, embolus, embrace, emulsify, emulsionize, flock together, flow together, forgather, freeze to, fumbler, fuse, gang around, gang up, gather, gather around, gawk, gel, gelatinate, gelatinize, golem, gowk, grasp, grow together, grume, half-wit, hang on, hang together, herd together, hive, hold, hold on, hold together, horde, huddle, hug, idiot, imbecile, incrassate, inspissate, jell, jellify, jelly, juggins, klutz, knot, league, legumin, link, looby, lopper, loppered milk, lout, lubber, lump, mass, meet, merge, mill, mongoloid idiot, moron, muster, natural, natural idiot, natural-born fool, oaf, ox, paracasein, persist, rally, rally around, rendezvous, seethe, set, simp, simpleton, slouch, slubberer, solidify, stay, stay put, stick, stick together, stream, surge, swarm, take hold of, thick, thicken, thrombus, throng, unite, whip, yokel
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